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ҩѧרҵ֪ʶһ

2018-10-11 18:01:43 Ա http://sd.huatu.com/ Դδ֪

1.ҩķࣺѧϳҩԴȻҩ\ҩ
 
2.ҩưҩͨѧƷ.
Ʒ:ҩղƷ,ӵרȨ.ͨ:ʷרҩƷƣINN
ѧ:ҩƷѧṹ
3.ͷ෽̬ɢϵƷʱ䡢ҩ;
Ͱҩ;
Ƿθ-ж׹ЧӦ
4.ҩĻѧ;
ˮҩオҪ;ˮ⣺ࣨΪӦĽṹǻϩάCࣩ
5.       ӰҩƼȶԵ
أpHҺƼ߻ܼԡǿȣ߻ӦԼлʻμ
6.ӰҩƼȶԵ
أ¶ȡߡӡʪȺˮּװϡ
 
7.ҩȶ鷽
Ӱ飨¡ʪǿ䣩
ڼ
۳
8.ҩƷЧڣ⣩
ҩオ10%ʣ90%Ҫʱ䡣
ʽt0.9=0.1054/k
 
t1/2=0.693/k
 
9.ҩƷװʹ÷ʽࣺ
ҩģҺҩģ粣Һƿ
ҩģҺƿǡϸǡ
10.ˮԻ֬Թ߻ͶҩЧҩڵաֲйˮ֬ࣨлࣩ࣬η䣬Ҫҩ֬Ժˮԡ 11.֬ˮϵҩˮԻ֬ԴСı׼Pʾ壺ҩˮʵŨˮʵŨ֮ȡ
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12.ҩӽṹıҩ֬ˮϵӰȽϴ
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13.    ҩѧࣺܽԣˮԣ͸ԣ֬ԣ
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14.գй
04
15.֬
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ǻϻˮǿ
 
16.ʹˮĻҪǻᡢᡢ淋ȣͨĤŶʹ֬μǻˮǿ֬ԲǻĻˮԺãˮų
17.ҩðбϵĻѧʣۼ棩ͷǹۼ棩
 
18.
1.ߵͬҩԺǿȣͪ
2.ͬҩԣǿͬȱ
3.һлԣһûлԣL-׻ͣϩ
19.෴ĻԣǶ䣬
5.ͬ͵ҩԣұӣᶡ
6.һ־ҩԣһ־߶ԣȰͪҰ
 
20.תͨΪࣺ
ڢתҩĹŻӦڵøҩӽеԭˮ⡢ǻȷӦ
21.IIϣȩᡢᡢ׸ģ׻ϷӦ
ĴС
22.ɢ
ڷϸۣáˡشϸ
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23.ʱޡɢܣ3min
¡ڣ5min
ͨ15min
Ĥ£30min
ܣ60min
24.ƬĴ
ԱۣǾҲò;ˮʪϣ۽άٲ;ƻɵۣȡڽ;󻬵òþͣҶ
 
25.ƬƱеij⼰ԭ
Ƭ(ϸ۶ࡢԲ)
Ƭ(Բѹ)
ٻ(ѹǿܲ)
ܳ(⡢ӲܽȲ
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:潺
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28.Һҩص
ٷɢȸ
տ죬ЧѸ
׽ʧЧ
ܷǾȶ
 
29.ҺƼܼ
:ˮ͡׻DMSO
뼫:ҴPEG300600
Ǽ:֬͡Һ״ʯڷ
30.ҺƼõĸӼ
ܼ:Լ→ɽ£HLB15-18
ܼ:→KIܼI2→KI3
DZܼ:ܼ→ˮҴ///PEG
31.
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34.ص
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35.Ҫ
 
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36.ȶ
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37.ֲڰ˥ڶ̡л죬Dzܿڷҩ 38.עҪ
pH49ѪҺ7.4
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עĩܼעϡͼ
39.Ƥʼ
ɵɺ⻯ɵɣȻڡǰҩ⻯ɵɣ֬ԣҩЧӳʱ䡣
ɺ⻯ɣ˫
40.עĸӼ
ơƣƫ
ơƣƫ
ϼҶƣEDTA·2Na
41.黯֬֬
ֹʹ³࿨
ڼȻơǡ
42.ԭ
ԡˮԡԡԡӷԡƻ
43.黯
O/WҴࡢ֬ᣨࣨʮƣɽ
W/Oë֬֬
44.
ѹ
Ʒ

ҺҺҺ
45.

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46.˨Ļ
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47.
֬ԻʣӲ֬//⻯ֲ//
ˮԻʣٸPEG
۲ɳķӲ֬
48.ȻۼغͪϩͪغͪǿϩͪԶغͪתΪغͪϵغͪʽ
غͪĿģʱɿڷ
49.ɢ
͹ۻ΢
̬Һ
/̬壺ǽᾧ޶
50.ƼҪ
ܽ
ڶҩһԼ
й©
ܶ/
51.Ƽص㣺
ȱ㣺
1.↓
2.
3.
 
 
52.Ƽҩԭ
ܳ
ɢ
ʴܳɢ
͸ѹ
ӽ
53.Ƽķ
ҩĴ״̬ṹ
Ǽͣ
ͣĤͣ
͸ͣ
54.Ƽijø
ǼͣˮCMC-NaMCHPMCPVPķΡǾ——ˮγ
ܣۼ׻ϩECϩ
55.Ƽ
ԭ֣ѧ
 
56.Ƽ֬塢΢顢 ΢΢ҡң
εҩ塢ǰҩ
ѧԡСpHС˨
57.
ȡre
Чte
ŨȱCe
58.֬Ҫ
01
59.Ѫҩ
4ࣺȵطڴٽȵαøƼȩǻԭøƼ
1ȵطڴٽṹ
 
60.ҩղλʮָСϲ
ҩղλ᳦
˨ҩղλֱ
 
 
 
61.տ˳
ڷҺңƬƬ
ע䣺ˮҺˮҺҺO/WW/OͻҺ
 
62.ҩķθ
עҩ
iv100%imҺҺɳЧƤ-ֲȵ
63.ҩĿĤת˷ʽ
תʴӸŨŨתˡתٶĤŨȲȣת˹̲Ҫ壬ޱ;ҩַʽͨĤ
64.תҩͨĤתʱøϵͳԴĤĵŨһŨһתˣֹ̳Ϊתˡ
65.ת˵ص㣺1Ũݶת

3תҩٶйأɳֱ
66.ת˵ص㣺
4ṹʷ
5вλ
 6תнṹ
 7ܴлƼӰ
67.׻ɢָһЩϸĤİ£ĤĸŨһŨһת˵Ĺ̡׻ɢоƣҲб 68.Ĥת
   ĤһԣͨΣĤûҺλ΢ijЩϸڻϸͷŵϸ⣬˹̳Ĥתˡ
69.Ӱҩյ
1.θҺijɷ
2θ˶
3ѭϵͳת
70.Ӱҩյļ
ڷҩöȣ
        ҺɢҼƬ
  ھˮɢƬ
71.ע䣺ˮҺˮҺҺO/WW/OͻҺ 72.Ӱҩֲ
ҩ֯׺
ѪҺѭϵͳ
ҩѪ׽ϵ
΢ҩϵͳ
ܰϵͳתˡѪϡ̥
73.΢ҩϵͳ
2.510μmϸ7ΡƢ7Σ
200400nmڸκѸٱ10nm
74.Ӱҩл
ҩ;ͼ
ҩ
лӦѡ
øյø
̬
75.2ǻȵطڴٽ“ʱѪǵڼ”ΡǸΡ׸Ρ˫ңǿԡȫԭų
ͪṹ޸ͪͪ
76.ҩйҪйǣ
Ҫлǣ
77.ҩãҩ໥ijʼãǶ
ҩЧӦ巴Ӧľ֣Ǽ̷ҩõĽϵȺ˳úЧӦ
78.ҩ
ƣҩԭ²ӣҩ
ʹÿɱԭ΢ﵽƸȾԼƼȱƶѪȡ
79.֢ƣҩܸƻ߼֢״
Ӧýʹҩ͸Ȼߵ£ʹͻĽʹѪѹҩͻ߹ߵѪѹڶ֢ơ
80.ЧϵҩЧӦĹϵһΧڣҩļŨȣӻʱЧӦ֮ǿ߼ԡ
81.ҩЧӦǿΪ꣬ŨΪ꣬õֱ˫ߡŨȻöֵͼֵ͵Sߣ-Чߡ 82.ӦҩЧӦǿı仯ӦİٷʱʾѪѹʡѪŨȵȣоΪһ塣 83.ʷӦҩЧӦҩŨȵı仯ΪӦʱ仯һԻԡȫ޵ķʽʾ벻ʡ˯ȣоΪһȺ塣
 
84.б
ЧӦԼ16%84%Ч߼һֱߣнǵֵΪЧߵбʡбʴҩҩ΢Сı仯ЧӦԸı䣻֮Ȼ
85.бʴСһ̶ϷӳٴҩļȫΧ
άD3ڸǻڸתΪǻپлΪǻž߻
86.СЧмҩЧӦСҩ
СЧŨȣŨȣҩЧӦҩŨȡ
87.ЧӦEmaxЧ
һΧڣҩŨȣЧӦǿ֮ӣЧӦʱӼŨȣЧӦЧӦΪһޣЧӦЧܡ
88.Чǿͬҩ֮ĵЧŨȵıȽϣָЧӦһ50%ЧӦԼŨȣֵԽСǿԽЧܷӳҩڻԡ
89.β࿹ҩ
кĸԭɵβԵıţùࣨ򻷣ͷ߾ࣨ⻯ົ͵βࡣ
90.ЧED50
50%ԷӦʷӦ50%ЧӦӦŨȻֱðЧED50ЧŨȣEC50ʾʾҩҩЧֵԽ󣬱ҩЧԽ
91.ָTILD50/ED50
ʾҩİȫԣֵԽԽȫ
ָҩﲻһȫΪЧ붾ЧߵβԿܳصED95ܴ5%жLD5
92.ҩãҩСӵ໥ãܵĸı䡣
 
93.ҩϵIJλҩõİе㡣֪е漰塢øͨᡢʡʡӰʼת塢ϵͳء򣩡 94.һ鵼ϸźתܵĴӵʡ
壺Խϵʡ߸ʶ
䵱һʹɫ
95.
.
.
.

96.ͣĴͣĤһˣ
.Gż
.ſصͨ

.ϸ˼
97.õźת
һʹָ༤ء񾭵ʡϸӼҩϸʹʡ
һʹܽϸ
98.ڶʹ
緢ֵĵڶʹǻգcAMP
лգcGMPͣDGἡIP3PGsCa2+إ̼ϩһNOȡ
99.֣ҿɿڷ֣ùøȶɿڷ֣߿ԾԣɿڷĹ׿أöȵͣĪ֣ǻ߿ڷöȣֺ־߿ٵԡ 100.ʹָϸϢݵʣӡתӵȡ
NOеһʹҲеڶʹ
101.ҩϲЧӦҪ׺Ҫڻԡҩ׺ȣЧӦȡڻǿڻʱȡ׺ĴС 102.ڻαʾ0≤α≤100%
ȫҩα=100%
ּҩнǿ׺ڻα<100%-Ч߸߶ȣEmaxϵ͡
 
103.  ҩ׺ڻ
ȫҩ׺ڻԣα=1ܸߣ
ּҩ׺ߣڻԲǿ0<α<1
104.׿ҩнǿ׺ȱڻԣα=0ʲܲЧӦռһ壬׿ҩá
105.׿ҩ뼤ҩྺͬϣãӼҩŨȣʹҩЧƽƣЧӦ䣬ǾƵҪ 106.׿pA2ʾ׿ҩ׺Сӳ׿ҩ伤ҩ׿ǿȡ 107.ĵڷʽ͡
ڳʹһּҩ֯ϸԼҩԺͷӦ½
108.ͬԴֻһ弤ҩķӦ½弤ҩķӦԲ䡣
ԴһͼҩļҩҲС
109.Ӱҩõأҩأҩʡԣиҩҩ;ҩʱ䡢Ƴ̣ϲҩҩ໥õȡ 110.Ӱҩõأ
أ䡢Ա塢߲״Ŵصȡ
111ԣҩ䷴ӦԻ𽥽ͣҪӴҩάԭЧ
ҩԻҩԣԭ΢ԿҩԽ͡ʧ
112.  ҩԣijЩҩҩ󣬿ʹҩĻĻ֮һ
ۺжҩɲһǿҵ֢״𺦡𽥼ͣҩ
113.ҩͬʱһʱʹֻϵҩ壺ҩЧڼٻ򽵵ҩﲻӦӻԻԭҩԣƳ̣Ӷҩ 114.ҩ໥ÿַʽ
ҩ໥ã
ҩѧҩ໥ã
ҩЧѧҩ໥á
115.Ӱҩ
ڷõĸҩ;ҩθʱ໥ӰأpHӰ죻ӵãθ˶Ӱ죻չܵӰ죻á
116.Ѫ׽ϲλ
ҩԣľͷˣٲҩԣڲͨѪ-ϣ۲лܲйֻҩҩá
117.øյøյʹӰҩü̡
øյƽƽͱסӢơͪһùءˮȩɲס³ءױ
118.øƣøƵĽʹһҩĴлǿӳá
øƼͪມߴ׼򡢺ùء俵ȱມùء涡¡࿹ҩ
119.ҩй;
1.С˹
2.Сܷ
3.С
 
120.ҩ໥õԤⷽ
ɸ飻
лԤ⣻
ݻ߸Ԥ
121.ҩƷӦADRDzҩĿIJߴʻʹķӦҹҩƷӦͼ취ĶΪָϸҩƷ÷³ֵҩĿ޹صĻкӦ 122.ҩﲻ¼ҩƹκβҽѧ¼ҩﲻ¼һҩϵ
ҩﲻ¼ҩƷӦҩƷ׼ȱݡҩƷ⡢ҩʧҩõȡ
123.ҩƷӦĴͳ
AͲӦҩҩǿIJӦ̶ҩйأԤ⣬ʽϸߣʽϵ͡áԷӦЧӦ׼ЧӦ̷Ӧͣҩۺȡ
124.ͳBͲӦ
ҩﳣҩ޹ص쳣ӦԤھ廼Ƿ֣ҩ޹أʽϵͣʽϸߡ
ʷӦӦ
125.CͲӦ
ҩƷҩ޹ص쳣Ӧ
ڳҩ֣DZڽϳҩƷͲӦ֮ûȷʱϵ
126.ãӦ
ҩﰴ÷ʹãĿ޹صIJʷӦ
ЧӦͣҩѪҩŨѽЧŨʱԲдҩЧӦ
127.ҩƷӦµķ
AࣺҩʼصķӦ
Bࣺٽ΢Bugs
FࣺFamilyŴȱ
128.ҩƷӦµķ
CࣺҩμĻѧChemical
DࣨضҩDeliveryʽ
EࣨҩExitӦ
 
129.  ҩƷӦµķ
HࣨӦ
Uࣨδ෴Ӧ
Gࣨ°»ȻGeneԷӦ
 
130.ҩƷӦϵ
1.ʱ
2.׺
3.ҩ
4.ٴҩ
5.Ӱ
131.΢:KarchLasagna϶ܿܡܡͿɣ5׼ҹADRIJõADRۣ6׼϶ܿܡܡ޹ءۺ޷ۡ 132.
ֳݼкۣΪڣ
1.źų
2.źżǿ
3.ź
 
133.ҩᆵҪ
ڷδ֪ҩƷIJӦ໥ã
ڷ֪ҩƷIJӦƣ
۷ҩƷӦķغͿܵĻƣ
ܶԷ/Ч۽жϢٽҩƷලָٴҩ
 
134.ҩᆵҪ
ܶԷ/Ч۽жϢٽҩƷලָٴҩ
135.ҩԴԼҩշԼҩԭ»֯ٷԻ𺦣ɴ˲ٴ֢״ļ 136.ҩԴ
˥
˥ߵҩз忹ҩѪܽתøƼصȡ
137.ۺ
ۺҩнΡùȡ
Сܹ
138.Ѫˮ
ŵȡ
 
139.ҩԴԶϰ
࿹ء忹ҩЧҩűҩͿҩȽDZڵĶԡ
140.ҩвѧҪо
ооʵо
141.ҩãҽĿĵʹþDZܵľʵΪ 142.עǻelg
02
143.ѪգFǹؼ
05
144.˫ģABӣ±10
06
145.ö
ָ꣺ʱ䣺tmax ŨȣCmax
C-tAUC
ó̶ EBA
յĶ——C-tAUC
146.ЧԣBE
ٸһҩIJͬƼͬ¸ͬӳճ̶ȺٶȵҪҩѧͳѧ졣
۲AUCtmaxCmax
147.ҩƷ׼ɣл񹲺͹ҩ䡷ҩƷ׼ҩƷע׼䲼ʳƷҩƷලܾ֣CFDA 148.ҩƷ׼ƶԭ
1ĿƶҪԣ
2鷽ѡҪпѧԣ
3׼޶ȵĹ涨Ҫкԡ
149.ҩ䡷ƣUSP
Ӣҩ䡷ƣBP
ձҩַƣJP
ŷҩ䡡ƣPh.Eur.EP
йҩ䡷ӢдCh.PCP
150.ڹ⣺ò͸װɫֽɫ͸͸
ܹ⣺չֱ䣻
20棻
ܹⲢ20棻
151.䴦2桫10棻
£10桫30棻
ע⣺£25±2棩
152.׼Ʒ—춨Ч۲ⶨı׼ʣֵЧ۵λμgƣԹʱ׼Ʒ궨

 
153.ܳƶȡӦ׼ȷȡǧ֮һƶȡӦ׼ȷȡİٷ֮һԼָù涨±10%ʮ֮һȷȾЧλȡСλҪ1λ 154.ȡҪ
1ͬʵԵIJֲƷȡѧ
2n≤100ʱݡҩƷָԭȡ
3n100ʱȡӦΪN
4ȫಿλȡ
5һȡһΪ3ȫҩƷ2ȫ
155.ͱࣺ
壨ͱᣩ
ͱã55ȡ໯Ч
ͱס˾ɰͱףСЧʹҩ
156.Ӣƣʹлѧ
ױӢƣӢǰҩעѸ١
157.ԲλģͣҪϵ㣺һӲλһʺϷƽ̹һӦİ۲λ
Чȣԡٴ
158.ǿͪƬ崿޼ƣʹ޷ⶥЧӦֻڲܵĸá
ϩȺͪN׻ϩ׻򻷶׻ȡ
159.ण4ʹҩԣǰҩɱѪеøˮʹԵᡣ
̫᣺4ʹҩ֬ԸߣͨѪ
160.ˮʹҩˮᣨ˾ƥ֣ȻԡˮˮᡣDZҪҩЧšøCOXƼѪСۺͷֹѪ˨γɡ
161.ʹҩӣϢʹˮ԰ӣԴ󣩣ڴлɾԺ͸ζԵǰⶾúϻṹҩ׸Ļװ 162.ŵ+˾ƥ֣ǰҩ
࿹ҩ
඾Ժ͵ڰ˶𺦣𲻿ԶͯԸ
163.ࣺᣨǰҩЧھδлԭΪлԵļ˫ȷᣨúǿҩС 164.ңS칹ԱȣR칹ǿ28Уڻᷢ칹תЧģR칹תΪЧģS칹塣
165.ࣺѡԵCOX2ƼӻࡣCOX2ѡƼ޷ṹ󣬳ѡԡȻҩѪ¼ķա 166.ʹҩ
ˮɼʹ缱֢ʹáҩƣθӦжǰס
棺ҩ﷢л໥ӰҩЧҩЧЧŨȣ
167.ɴǿѸ٣ȡʹȡԼ8%лȣԣ
ŵͪ࿹ҩðе㣺DNAø칹ø
168.ɳң૽ṹҪƸɿȡʹáӳɳãȴʹã
ҩ
ҰἤøƼ
 
169.ƽҩ
β2弤βҰṹɳز಼֡ޣزֵǰҩࡣ
169.Ӱϩƽҩͨɫƣʴϸȶսṹı˫ɫͪ8%ڷ0.5%˾أͼ˾ࡣ 170.M׿狀李ҩЧţЧֹҩϵͳ 171.ƤʼأᱶɣգδлøԽͣ޻ԣ濨ɺͲε¡
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